Jick H, Porter J
Lancet. 1978 Jul 8;2(8080):87-9. doi: 10.1016/s0140-6736(78)91396-x.
Rates of drug-induced gastrointestinal bleeding were estimated from data on 16 646 consecutively monitored medical inpatients who had no known predisposing illness. Heparin, warfarin, ethacrynic acid, steroids, and aspirin-containing drugs were associated with gastrointestinal bleeding and were estimated to account for about two-thirds of such bleeds. Major gastrointestinal bleeding, defined as bleeding severe enough to require transfusion, occurred in only 57 patients (0.3%).
药物性胃肠道出血的发生率是根据对16646名连续监测的无已知易患疾病的内科住院患者的数据估算得出的。肝素、华法林、依他尼酸、类固醇以及含阿司匹林的药物与胃肠道出血有关，据估计约占此类出血的三分之二。严重到需要输血的大出血仅发生在57名患者中（0.3%）。
