脱氧核糖核酸聚合酶III在修复γ射线导致的大肠杆菌脱氧核糖核酸单链断裂中的作用
Role of deoxyribonucleic acid polymerase III in the repair of single-strand breaks produced in Escherichia coli deoxyribonucleic acid by gamma radiation.
作者信息
Hamelin C, Youngs D A, Smith K C
出版信息
J Bacteriol. 1976 Sep;127(3):1307-14. doi: 10.1128/jb.127.3.1307-1314.1976.
Abstract
Cell survival, deoxyribonucleic acid (DNA) degradation, and the repair of DNA single-strand breaks were measured for Escherichia coli K-12 pol+, polA1, polC1026(ts), and polA1 polC1026(ts) cells after 137Cs gamma irradiation. The results indicate that DNA polymerase III is required for growth medium-dependent (type III) repair in polA+ or polA cells. In pol+ or polC cells, DNA polymerase I performs type II repair efficiently. The relative deficiencies of each of these strains in DNA repair generally correlate with their relative sensitivities to cell killing and with the extent of DNA degradation observed.
摘要
对经137Csγ射线辐照后的大肠杆菌K-12野生型（pol+）、polA1突变型、polC1026（温度敏感型）和polA1 polC1026（温度敏感型）细胞进行了细胞存活、脱氧核糖核酸（DNA）降解及DNA单链断裂修复的测定。结果表明，在polA+或polA细胞中，DNA聚合酶III是依赖生长培养基的（III型）修复所必需的。在pol+或polC细胞中，DNA聚合酶I能有效地进行II型修复。这些菌株在DNA修复方面的相对缺陷通常与其对细胞杀伤的相对敏感性以及观察到的DNA降解程度相关。
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