Wang Z, Young S R, Liu L, Dawson W D
Department of Biological Sciences, University of South Carolina, Columbia.
Cytogenet Cell Genet. 1995;69(1-2):97-100. doi: 10.1159/000133946.
Mus domesticus DNA probes for the tumor suppressor protein-53 (Tp53) and thymidine kinase-1 (Tk1) genetic loci were used to identify clones representing these loci in a Peromyscus leucopus (white-footed mouse) cosmid library. The cosmid-derived homologous probes were biotinylated and hybridized to P. maniculatus (deer mouse) chromosomes. Probes for both genes hybridized to the chromosome 13 pair identified by prior G-banding. Deer mouse chromosome 13 shares a region of homology with mouse chromosome 11, rat chromosome 10 and human chromosome 17.
利用小家鼠（Mus domesticus）中肿瘤抑制蛋白-53（Tp53）和胸苷激酶-1（Tk1）基因座的DNA探针，在白足鼠（Peromyscus leucopus）黏粒文库中鉴定代表这些基因座的克隆。将黏粒衍生的同源探针进行生物素化，并与鹿鼠（P. maniculatus）染色体杂交。两个基因的探针均与先前通过G带分析鉴定出的第13号染色体对杂交。鹿鼠的第13号染色体与小鼠的第11号染色体、大鼠的第10号染色体和人类的第17号染色体存在同源区域。
