Reif J S, Lower K S, Ogilvie G K
Department of Environmental Health, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.
Am J Epidemiol. 1995 Feb 15;141(4):352-9. doi: 10.1093/aje/141.4.352.
A hospital-based case-control study was conducted to determine whether residential exposure to magnetic fields increased risk for canine lymphoma in pet dogs. Cases were patients at a veterinary teaching hospital with histologically confirmed lymphoma diagnosed between 1987 and 1990. Hospital controls with other forms of cancer were obtained by frequency matching on zip code and year of diagnosis. Information regarding the dog's activity patterns, residence history, and exposure to potential confounders was obtained by telephone interview. Wire codes and magnetic fields were measured at the homes at diagnosis of 93 cases and 137 controls. When exposure was categorized into two levels (high or very high wire codes compared with low, very low, or buried lines), the risk was elevated (odds ratio (OR) = 1.6, 95% confidence interval (CI) 0.9-2.9) and increased (OR = 1.8, 95% CI 0.9-3.4) after adjustment for potential confounders. Dogs that lived in homes with very high current codes had the highest risk (OR = 6.8, 95% CI 1.6-28.5). Moderate, imprecise increases in risk (odds ratios of 1.5-1.9) were found for residence in a home with a sidewalk (plumbing), backyard, or front yard magnetic field of 2.0 mG or greater, but not for indoor measurements at this level. Risk increased among dogs that spent more than 25% of the day outdoors. Laboratory and observational studies of dogs as an animal model for the effects of magnetic fields are recommended.
开展了一项基于医院的病例对照研究，以确定宠物狗居住环境中暴露于磁场是否会增加患犬淋巴瘤的风险。病例为一家兽医教学医院在1987年至1990年间经组织学确诊为淋巴瘤的患者。通过按邮政编码和诊断年份进行频数匹配获得患有其他癌症形式的医院对照。通过电话访谈获取有关狗的活动模式、居住史以及暴露于潜在混杂因素的信息。在93例病例和137例对照诊断时对其家中的电线代码和磁场进行了测量。当将暴露分为两个水平（高或非常高的电线代码与低、非常低或地下线路相比）时，在对潜在混杂因素进行调整后，风险升高（比值比（OR）= 1.6，95%置信区间（CI）0.9 - 2.9）且有所增加（OR = 1.8，95% CI 0.9 - 3.4）。居住在电流代码非常高的房屋中的狗风险最高（OR = 6.8，95% CI 1.6 - 28.5）。对于居住在人行道（管道）、后院或前院磁场为2.0毫高斯或更高的房屋中，发现风险有中度、不精确的增加（比值比为1.5 - 1.9），但在这个水平的室内测量中未发现。在一天中超过25%时间在户外的狗中风险增加。建议开展以狗作为磁场影响动物模型的实验室和观察性研究。
