Müri R M, Rivaud S, Timsit S, Cornu P, Pierrot-Deseilligny C
Laboratoire INSERM 289, Hôpital de la Salpêtrière, Paris, France.
Exp Brain Res. 1994;101(1):165-8. doi: 10.1007/BF00243227.
The role of the hippocampal formation in the control of memory-guided saccades is unclear. We tested two types of memory-guided saccades with short memorization delay in three patients with a lesion affecting the right medial temporal lobe and involving the hippocampal formation. In single memory-guided saccades, testing spatial working memory, the gain of the patient group did not differ from that of an age-matched control group. In contrast, in sequences of memory-guided saccades, testing chronological working memory, there was a marked and significant increase in the percentage of erroneous sequences in patients, compared to controls. These results suggest an important role of the hippocampal formation in the memorization of the chronological order of saccade sequences. In contrast, this structure does not appear to be crucial for spatial working memory, used in single memory-guided saccades.
海马结构在记忆引导扫视控制中的作用尚不清楚。我们对三名右侧颞叶内侧受损且累及海马结构的患者进行了两种记忆引导扫视测试，记忆延迟较短。在单记忆引导扫视测试空间工作记忆时，患者组的增益与年龄匹配的对照组无差异。相比之下，在记忆引导扫视序列测试时间顺序工作记忆时，与对照组相比，患者错误序列的百分比显著增加。这些结果表明海马结构在扫视序列时间顺序的记忆中起重要作用。相比之下，该结构在单记忆引导扫视中使用的空间工作记忆方面似乎并非至关重要。
