Gomi S, Amano S, Sato E, Miyadoh S, Kodama Y
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
J Antibiot (Tokyo). 1994 Dec;47(12):1385-94. doi: 10.7164/antibiotics.47.1385.
Three new antibiotics SF2738A, B and C, and their analogs were isolated from the culture broth of Streptomyces sp. The antibiotics are active against Gram-positive bacteria, Gram-negative bacteria and fungi, and exhibited cytotoxic activity against P388 murine leukemia cells with IC50 values of 0.08, 0.25 and 7.5 micrograms/ml, respectively. Their structures were determined by spectral analyses and chemical conversion. Especially, the structure of SF2738A was confirmed to be (E)-((4-methoxy-5-methylthio-2-(2-pyridyl)pyridin-6-yl)methylene)azan ol by X-ray crystallographic analysis.
从链霉菌属的培养液中分离出三种新抗生素SF2738A、B和C及其类似物。这些抗生素对革兰氏阳性菌、革兰氏阴性菌和真菌具有活性，并且对P388小鼠白血病细胞表现出细胞毒性活性，IC50值分别为0.08、0.25和7.5微克/毫升。通过光谱分析和化学转化确定了它们的结构。特别是，通过X射线晶体学分析证实SF2738A的结构为(E)-((4-甲氧基-5-甲硫基-2-(2-吡啶基)吡啶-6-基)亚甲基)氮杂环丁烷醇。
