Baken L A, Koutsky L A, Kuypers J, Kosorok M R, Lee S K, Kiviat N B, Holmes K K
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle.
J Infect Dis. 1995 Feb;171(2):429-32. doi: 10.1093/infdis/171.2.429.
Penile, cervical, and vulvovaginal samples from 50 couples attending a sexually transmitted disease clinic and perianal samples from women only were tested for human papillomavirus (HPV) DNA by dot filter hybridization (DFH) and polymerase chain reaction (PCR). Only 18% of women and 4% of men were HPV-positive by DFH, but 72% of women and 63% of men were HPV-positive by PCR. HPV type-specific concordance between partners was more common than predicted by chance (P = .01) and was associated with detection of HPV DNA by DFH in either partner. Thus, genital HPV infection in this population is common in both men and women, and the HPV type-specific concordance in sex partners is consistent with sexual transmission. Higher levels of genital or perianal HPV, as reflected by detection of HPV DNA with the less-sensitive DFH method, may promote sexual transmission.
对50对前往性传播疾病诊所就诊的夫妇的阴茎、宫颈和外阴阴道样本以及仅女性的肛周样本进行检测，采用斑点杂交（DFH）和聚合酶链反应（PCR）检测人乳头瘤病毒（HPV）DNA。通过DFH检测，只有18%的女性和4%的男性HPV呈阳性，但通过PCR检测，72%的女性和63%的男性HPV呈阳性。性伴侣之间HPV型特异性一致性比偶然预期的更常见（P = 0.01），并且与任何一方通过DFH检测到HPV DNA相关。因此，该人群中的生殖器HPV感染在男性和女性中都很常见，性伴侣之间HPV型特异性一致性与性传播一致。用敏感性较低的DFH方法检测到HPV DNA所反映的生殖器或肛周HPV水平较高，可能会促进性传播。
