Gómez-Jiménez J, Martín M C, Sauri R, Segura R M, Esteban F, Ruiz J C, Nuvials X, Bóveda J L, Peracaula R, Salgado A
Department of Biochemistry, Vall d'Hebron General Hospital, Autonomous University, Barcelona, Spain.
J Infect Dis. 1995 Feb;171(2):472-5. doi: 10.1093/infdis/171.2.472.
Interleukin (IL)-10 is a potent immunosuppressant of monocyte/macrophage function and may help control the inflammatory response induced by bacterial infection. To analyze whether IL-10 is detectable in plasma of patients with septic shock and to evaluate its relationship with endotoxin (lipopolysaccharide [LPS])-induced and monocyte/macrophage-induced inflammatory response, plasma IL-10, tumor necrosis factor (TNF)-alpha, IL-1 beta, IL-6, IL-8, LPS, and neopterin were studied in 24 patients with septic shock and in 12 critically ill patients. Eighty-three percent of patients with septic shock and 25% of critically ill patients had detectable levels of IL-10 (P < .001). There was a significant correlation between plasma IL-10, neopterin (r = .72), TNF-alpha (r = .76), IL-6 (r = .68), and IL-8 (r = .61) levels in patients with septic shock. Monocyte/macrophage activation leads to massive secretion of IL-10, which, however, seems to be unable to control the increased production of proinflammatory mediators during septic shock.
白细胞介素（IL）-10是单核细胞/巨噬细胞功能的一种强效免疫抑制剂，可能有助于控制细菌感染诱导的炎症反应。为了分析脓毒性休克患者血浆中是否可检测到IL-10，并评估其与内毒素（脂多糖[LPS]）诱导的以及单核细胞/巨噬细胞诱导的炎症反应的关系，对24例脓毒性休克患者和12例危重症患者的血浆IL-10、肿瘤坏死因子（TNF）-α、IL-1β、IL-6、IL-8、LPS和蝶呤进行了研究。83%的脓毒性休克患者和25%的危重症患者IL-10水平可检测到（P <.001）。脓毒性休克患者血浆IL-10、蝶呤（r =.72）、TNF-α（r =.76）、IL-6（r =.68）和IL-8（r =.61）水平之间存在显著相关性。单核细胞/巨噬细胞激活导致IL-10大量分泌，然而，在脓毒性休克期间，IL-10似乎无法控制促炎介质产生的增加。
