Brooks J D, Bova G S, Isaacs W B
James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.
Prostate. 1995 Jan;26(1):35-9. doi: 10.1002/pros.2990260108.
Inactivation of the retinoblastoma (Rb) gene has been implicated in the genesis and progression of a number of tumor types, including prostatic adenocarcinomas. We have analyzed a series of 46 surgically-resected human prostatic adenocarcinomas for allelic loss of the Rb gene with PCR amplification of a highly polymorphic region of the gene. 41 of 46 tumors (89%) were informative and 11 of these (27%) had lost one Rb allele. The relative frequency of this occurrence suggests that inactivation of the retinoblastoma gene may be an important event in prostate carcinogenesis.
视网膜母细胞瘤（Rb）基因的失活与多种肿瘤类型的发生和发展有关，包括前列腺腺癌。我们通过对该基因一个高度多态性区域进行PCR扩增，分析了46例手术切除的人类前列腺腺癌样本中Rb基因的等位基因缺失情况。46例肿瘤中有41例（89%）信息明确，其中11例（27%）丢失了一个Rb等位基因。这种情况的相对发生率表明，视网膜母细胞瘤基因的失活可能是前列腺癌发生过程中的一个重要事件。
