Battaglia C, Artini P G, D'Ambrogio G, Genazzani A D, Genazzani A R
Department of Obstetrics and Gynecology, University of Modena, Italy.
Am J Obstet Gynecol. 1995 Jan;172(1 Pt 1):108-13. doi: 10.1016/0002-9378(95)90094-2.
Our purpose was to evaluate whether intraovarian and uterine blood flow variations are associated with clinical, ultrasonographic, and endocrine polycystic ovary syndrome findings.
Thirty-two hirsute, oligomenorrheic patients and 18 volunteer women underwent in the early follicular phase ultrasonographic evaluation of ovarian volume, echodensity, and follicle number; transvaginal color Doppler measurement of the uterine and intraovarian vessel variations; and radioimmunologic dosage of luteinizing hormone, follicle-stimulating hormone, estradiol, progesterone, testosterone, androstenedione, and other hormonal compartments.
In the patients with polycystic ovary syndrome (increased luteinizing hormone/follicle-stimulating hormone ratio, elevated androstenedione levels, high number of subcapsular follicles by ultrasonography-augmented ovarian volume and echodensity) (n = 22) we observed, at Doppler analysis, significantly elevated uterine artery pulsatility index values associated with a typical low resistance index of stromal ovary vascularization. The pulsatility index was positively correlated with the luteinizing hormone/follicle-stimulating hormone ratio, and the resistance index was negatively correlated. The elevated uterine artery resistance was correlated with androstenedione levels.
Doppler analysis can be a valuable additional tool for the diagnosis of polycystic ovary syndrome.
我们的目的是评估卵巢内和子宫血流变化是否与临床、超声及内分泌多囊卵巢综合征表现相关。
32名多毛、月经过少的患者和18名志愿者女性在卵泡早期接受了超声检查，评估卵巢体积、回声密度和卵泡数量；经阴道彩色多普勒测量子宫和卵巢内血管变化；放射免疫法测定促黄体生成素、促卵泡生成素、雌二醇、孕酮、睾酮、雄烯二酮及其他激素成分。
在多囊卵巢综合征患者中（促黄体生成素/促卵泡生成素比值升高、雄烯二酮水平升高、超声检查显示包膜下卵泡数量增多——卵巢体积和回声密度增大）（n = 22），我们在多普勒分析中观察到，子宫动脉搏动指数值显著升高，同时伴有卵巢间质血管化典型的低阻力指数。搏动指数与促黄体生成素/促卵泡生成素比值呈正相关，阻力指数呈负相关。子宫动脉阻力升高与雄烯二酮水平相关。
多普勒分析可为多囊卵巢综合征的诊断提供有价值的辅助手段。
