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人子宫内膜中间质胶原酶的表达受孕酮和雌二醇调控，且与月经有关。

The expression of interstitial collagenase in human endometrium is controlled by progesterone and by oestradiol and is related to menstruation.

作者信息

Marbaix E, Kokorine I, Henriet P, Donnez J, Courtoy P J, Eeckhout Y

机构信息

Cell Biology Unit, International Institute of Cellular and Molecular Pathology, Bruxelles, Belgium.

出版信息

Biochem J. 1995 Feb 1;305 ( Pt 3)(Pt 3):1027-30. doi: 10.1042/bj3051027.

DOI:10.1042/bj3051027
PMID:7848264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1136361/
Abstract

Human endometrial tissue, sampled at different periods of the reproductive cycle, expressed interstitial collagenase mRNA, protein and activity only just before and during the menstrual period. This clear-cut correlation and the inhibition of collagenase expression by progesterone and oestradiol in tissue culture point to a pivotal role of this proteinase in the mechanism of menstrual tissue breakdown and bleeding.

摘要

在生殖周期不同阶段采集的人类子宫内膜组织，仅在月经前期及月经期表达间质胶原酶信使核糖核酸、蛋白质和活性。这种明确的相关性以及在组织培养中孕酮和雌二醇对胶原酶表达的抑制表明，这种蛋白酶在月经组织崩解和出血机制中起关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f8c/1136361/8ad90448c559/biochemj00070-0331-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f8c/1136361/c18d0062cc28/biochemj00070-0329-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f8c/1136361/8ad90448c559/biochemj00070-0331-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f8c/1136361/c18d0062cc28/biochemj00070-0329-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f8c/1136361/8ad90448c559/biochemj00070-0331-a.jpg

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Expression and localization of matrilysin, a matrix metalloproteinase, in human endometrium during the reproductive cycle.
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Progesterone action in the myometrium and decidua in preterm birth.孕酮在早产时子宫肌层和蜕膜中的作用。
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A randomized controlled trial of subantimicrobial-dose doxycycline to prevent unscheduled bleeding with continuous oral contraceptive pill use.一项小剂量米诺环素预防持续口服避孕药使用者非计划性出血的随机对照试验。
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