Paris-Descartes University, Diagnosis and Therapeutic Center, Hypertension and Cardiovascular Prevention Unit, Hôtel-Dieu Hospital, AP-HP, 75004 Paris, France.
Centre de Recherche Clinique, Grand Hôpital de l'Est Francilien (GHEF), 77100 Meaux, France.
Int J Mol Sci. 2020 Mar 31;21(7):2440. doi: 10.3390/ijms21072440.
Endometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis. Oxidative stress, an imbalance between reactive oxygen species and antioxidants, could have a key role in the initiation and progression of endometriosis by resulting in inflammatory responses in the peritoneal cavity. Nevertheless, the mechanisms underlying this disease are still unclear and therapies are not currently efficient. Curcumin is a major anti-inflammatory agent. Several findings have highlighted the anti-oxidant, anti-inflammatory and anti-angiogenic properties of curcumin. The purpose of this review is to summarize the potential action of curcumin in endometriosis by acting on inflammation, oxidative stress, invasion and adhesion, apoptosis and angiogenesis.
子宫内膜异位症是一种常见的妇科疾病，其特征是子宫腔外存在腺体和基质。一些研究结果强调了炎症在子宫内膜异位症中的主要作用，通过作用于增殖、凋亡和血管生成。氧化应激是活性氧和抗氧化剂之间的失衡，可能通过在腹腔内引起炎症反应，在子宫内膜异位症的发生和发展中起关键作用。然而，这种疾病的发病机制尚不清楚，目前的治疗方法也不是很有效。姜黄素是一种主要的抗炎剂。有几项研究结果强调了姜黄素的抗氧化、抗炎和抗血管生成特性。本文综述的目的是总结姜黄素通过作用于炎症、氧化应激、侵袭和黏附、凋亡和血管生成，在子宫内膜异位症中的潜在作用。
