van Dobbenburgh J O, Lekkerkerk C, van Echteld C J, de Beer R
Interuniversity Cardiology Institute of the Netherlands, Utrecht.
NMR Biomed. 1994 Aug;7(5):218-24. doi: 10.1002/nbm.1940070504.
This study was conducted to verify the validity of using saturation factors obtained from unlocalized 31P spectra containing both chest wall and heart muscle signals for correcting human heart muscle phosphocreatine/beta-adenosine triphosphate (PCr/beta-ATP) ratios. Saturation factors and T1 relaxation times were determined from 31P magnetic resonance spectra of human chest wall and heart muscle simultaneously in healthy volunteers using one-dimensional spectroscopic imaging in combination with a two-dimensional ISIS sequence by using adiabatic 180 degrees inversion and adiabatic 90 degrees excitation pulses at 1.5 T. Blood corrected saturation factors for PCr/beta-ATP at a TR of 2.4 s were significantly different in heart muscle and chest wall muscle, 1.30 +/- 0.25 and 1.73 +/- 0.31, respectively (p < 0.05). T1 values for PCr and beta-ATP in heart muscle were 4.28 +/- 0.72 and 2.99 +/- 0.52 and in chest wall muscle 6.82 +/- 1.07 and 3.39 +/- 0.48, respectively. The T1(PCr)/T1(beta-ATP) ratios in chest wall and heart muscle were not identical. The mean PCr/beta-ATP ratios in heart and chest wall muscle of six healthy volunteers were 1.23 +/- 0.17 and 3.71 +/- 0.53, respectively.
本研究旨在验证使用从未定位的31P谱（包含胸壁和心肌信号）中获得的饱和因子来校正人体心肌磷酸肌酸/β-三磷酸腺苷（PCr/β-ATP）比值的有效性。在1.5T条件下，通过使用绝热180度反转和绝热90度激发脉冲，采用一维光谱成像结合二维ISIS序列，在健康志愿者中同时测定人体胸壁和心肌的31P磁共振谱，从而确定饱和因子和T1弛豫时间。在TR为2.4s时，心肌和胸壁肌肉中PCr/β-ATP的血液校正饱和因子存在显著差异，分别为1.30±0.25和1.73±0.31（p<0.05）。心肌中PCr和β-ATP的T1值分别为4.28±0.72和2.99±0.52，胸壁肌肉中分别为6.82±1.07和3.39±0.48。胸壁和心肌中的T1(PCr)/T1(β-ATP)比值并不相同。六名健康志愿者心肌和胸壁肌肉中的平均PCr/β-ATP比值分别为1.23±0.17和3.71±0.53。
