Colman P M
Biomolecular Research Institute, Parkville, Victoria, Australia.
Protein Sci. 1994 Oct;3(10):1687-96. doi: 10.1002/pro.5560031007.
The determination of the 3-dimensional structure of the influenza virus neuraminidase in 1983 has served as a platform for understanding interactions between antibodies and protein antigens, for investigating antigenic variation in influenza viruses, and for devising new inhibitors of the enzyme. That work is reviewed here, together with more recent developments that have resulted in one of the inhibitors entering clinical trials as an anti-influenza virus drug.
1983年流感病毒神经氨酸酶三维结构的确定，为理解抗体与蛋白质抗原之间的相互作用、研究流感病毒的抗原变异以及设计该酶的新型抑制剂提供了一个平台。本文回顾了该项工作，以及最近的进展，这些进展已使其中一种抑制剂作为抗流感病毒药物进入临床试验阶段。
