Baker B J, Scheuer P J
Department of Chemistry, University of Hawaii at Manoa, Honolulu 96822.
J Nat Prod. 1994 Oct;57(10):1346-53. doi: 10.1021/np50112a003.
Telesto riisei, an octocoral from Hawaii, produces nineteen highly functionalized prostanoids, the punaglandins, which are characterized by various oxygenation at C-5, -6, -7, and -12, and a 10-chloro-9-cyclopentenone moiety. The absolute stereochemistry of the 10-chloroprostanoids is epimeric to that of the Pacific marine prostanoids without halogen. The punaglandins have shown anti-inflammatory and antitumor activity. A synthetic 10-thiomethyl derivative enhances in vivo mineralization in human osteoblasts.
来自夏威夷的八放珊瑚Telesto riisei可产生19种高度官能化的前列腺素类化合物——普纳前列腺素，其特征在于C-5、-6、-7和-12位存在各种氧化作用，以及一个10-氯-9-环戊烯酮部分。含10-氯前列腺素类化合物的绝对立体化学与不含卤素的太平洋海洋前列腺素类化合物的绝对立体化学呈差向异构关系。普纳前列腺素已显示出抗炎和抗肿瘤活性。一种合成的10-硫代甲基衍生物可增强人成骨细胞的体内矿化作用。
