Farr G, Amatya R, Betancourt J D, David M, Alfonso L, Dacalos E
Family Health International, Research Triangle Park, NC 27709.
Contraception. 1994 Nov;50(5):417-29. doi: 10.1016/0010-7824(94)90059-0.
The clinical performance of the Copper T 380A (TCu 380A) and the Copper T 220C (TCu 220C) intrauterine devices (IUDs) were evaluated for 12 months in a group of women who had one of the two IUDs inserted. Results are from a randomized clinical trial conducted at four collaborating research sites located in two developing countries. The gross cumulative life-table pregnancy rate of the TCu 380A IUD was found to be lower than that of the TCu 220C IUD at 12 months (0.3 and 0.8, respectively), although this difference was not statistically significant (p > 0.05). Statistically significant differences between the two study IUDs were not found with regard to IUD expulsion or IUD removal due to bleeding/pain, personal reasons, medical reasons, or planned pregnancy. No statistically significant differences were observed in the frequency of experiencing menstrual disturbances (i.e., dysmenorrhea, intermenstrual pelvic pain or intermenstrual bleeding) between the two IUD groups. These data suggest that the TCu 380A and TCu 220C IUDs are both appropriate options for contracepting women. The TCu 380A IUD, however, may be a more appropriate option for those women wishing to space births over a longer period of time.
在一组插入了铜T 380A（TCu 380A）或铜T 220C（TCu 220C）宫内节育器（IUD）的女性中，对这两种IUD的临床性能进行了为期12个月的评估。结果来自于在两个发展中国家的四个合作研究地点进行的一项随机临床试验。在12个月时，发现TCu 380A IUD的总累积生命表妊娠率低于TCu 220C IUD（分别为0.3和0.8），尽管这种差异无统计学意义（p>0.05）。在IUD脱落或因出血/疼痛、个人原因、医学原因或计划妊娠而取出IUD方面，未发现两种研究IUD之间存在统计学显著差异。两组IUD在经历月经紊乱（即痛经、经间期盆腔疼痛或经间期出血）的频率上未观察到统计学显著差异。这些数据表明TCu 380A和TCu 220C IUD都是适合避孕女性的选择。然而，对于那些希望更长时间间隔生育的女性来说，TCu 380A IUD可能是更合适的选择。
