Le Huec J C, Schaeverbeke T, Chauveaux D, Moinard M, Rivel J, Le Rebeller A
Service de Rhumatologie, CHU Pellegrin, Université de Bordeaux II.
J Chir (Paris). 1994 Oct;131(10):408-12.
Epicondylitis occurred in two leisure athletes who were taking fluoroquinolones. No similar cases have been reported in the literature. In both cases, pain occurred early after initiating drug therapy. Pain was intense and was not controlled by usual care. Echography demonstrated major inflammatory lesions with pseudo-necrosis. Magnetic resonance imaging confirmed the lesions and gave evidence of infraclinical lesions of the adjacent tendons. Surgical disinsertion of the epicondyles with biopsy was indicated due to the persistent pain. Histological examination revealed unspecific lesions of hyalin degeneration and a few giant cells in one case. Pain disappeared after surgery and the patients were able to return to their work, but neither was able to continue his sports activity. Lesions of the Achilles tendon have been observed in patients taking fluoroquinolone and the two cases reported here confirm the possibility of other localizations. Care must therefore be taken when prescribing these antibiotics in patients at risk (dialysis patients, those on corticosteroids, high-performance athletes).
两名服用氟喹诺酮类药物的休闲运动员发生了上髁炎。文献中未报道过类似病例。在这两例中,疼痛在开始药物治疗后不久就出现了。疼痛剧烈,常规治疗无法控制。超声检查显示有伴有假坏死的严重炎症病变。磁共振成像证实了这些病变,并显示出相邻肌腱的亚临床病变。由于持续疼痛,建议进行上髁手术分离并活检。组织学检查显示一例有玻璃样变性的非特异性病变和一些巨细胞。术后疼痛消失,患者能够恢复工作,但两人都无法继续进行体育活动。服用氟喹诺酮类药物的患者中曾观察到跟腱病变,此处报告的两例病例证实了其他部位出现病变的可能性。因此,在给有风险的患者(透析患者、使用皮质类固醇的患者、高性能运动员)开这些抗生素时必须谨慎。