Dahl M V, Greene W H, Quie P G
Arch Dermatol. 1976 Oct;112(10):1387-90.
Eleven patients with recurrent bacterial infections were found to have impaired neutrophil chemotaxis. The infections were primarily staphylococcal abscesses involving the skin and the respiratory tract. All patients had chronic eczematour dermatitis and an elevated level of serum IgE. The peripheral blood eosinophil count was equal to or greater than 10% of the circulating leukocytes in 10 of 11 patients. Associated findings in some patients included urticaria and oral or cutaneous Candida infection. These observations suggest a relationship between chronic dermatitis, elevated serum IgE level, eosinophilia, defective neutrophil chemotactic responsiveness, and recurrent pyogenic infections of skin and lungs.
11例复发性细菌感染患者被发现存在中性粒细胞趋化功能受损。感染主要为累及皮肤和呼吸道的葡萄球菌性脓肿。所有患者均有慢性湿疹性皮炎且血清IgE水平升高。11例患者中有10例的外周血嗜酸性粒细胞计数等于或高于循环白细胞的10%。部分患者的相关表现包括荨麻疹以及口腔或皮肤念珠菌感染。这些观察结果提示慢性皮炎、血清IgE水平升高、嗜酸性粒细胞增多、中性粒细胞趋化反应缺陷与皮肤和肺部复发性化脓性感染之间存在关联。
