Becker G, Krone A, Koulis D, Lindner A, Hofmann E, Roggendorf W, Bogdahn U
Department of Neurology, University of Würzburg, Germany.
Neuroradiology. 1994 Nov;36(8):585-90. doi: 10.1007/BF00600414.
Transcranial colour-coded real-time sonography (TCCS) was carried out in 25 patients with brain tumours to determine whether this noninvasive method provides additional information about the extent of solid tumour, its differentiation from oedema, and its tissue components. All 25 patients had serial computed tomography (CT)-guided stereotactic biopsies. Comparison of ultrasound, CT and histological findings revealed that the vast majority of contrast enhancing areas on CT were hyperechogenic (32/33; 97%) and contained tumour tissue (29/32; 91%). Hyperechogenic areas always represented solid tumour (23/23 patients), even when CT showed low density non-enhancing lesions. In lesions hypoechogenic on TCCS and low density on CT, histology consistently revealed necrotic tumour (7/7). Biopsies obtained from parenchyma with normal echogenicity revealed tumour in only 3 of 16 specimens. Despite the high specificity of TCCS in the differentiation of tumour components, its sensitivity to tumour was inferior to that of CT (24/25; 96%). TCCS thus allows noninvasive preoperative identification of tumour tissue and its extent setting.
对25例脑肿瘤患者进行了经颅彩色编码实时超声检查（TCCS），以确定这种非侵入性方法是否能提供有关实体瘤范围、其与水肿的鉴别以及其组织成分的额外信息。所有25例患者均接受了连续计算机断层扫描（CT）引导下的立体定向活检。超声、CT和组织学检查结果的比较显示，CT上绝大多数强化区域为高回声（32/33；97%）且包含肿瘤组织（29/32；91%）。高回声区域始终代表实体瘤（23/23例患者），即使CT显示为低密度无强化病变。在TCCS上低回声且CT上低密度的病变中，组织学检查始终显示为坏死肿瘤（7/7）。从回声正常的实质组织获取的活检标本中，16份标本中仅有3份发现肿瘤。尽管TCCS在鉴别肿瘤成分方面具有高特异性，但其对肿瘤的敏感性低于CT（24/25；96%）。因此，TCCS能够在术前非侵入性地识别肿瘤组织及其范围。
