Pääkkö E, Talvensaari K, Pyhtinen J, Lanning M
Department of Diagnostic Radiology, University of Oulu, Finland.
Neuroradiology. 1994 Nov;36(8):652-5. doi: 10.1007/BF00600433.
We carried out MRI on 43 survivors of childhood cancer after different treatment protocols with or without cranial radiotherapy. They were free of disease, therapy having been discontinued 2-20 years earlier. Treatment had been for various malignancies, excluding brain tumours; 27 had received cranial irradiation for acute lymphoblastic leukaemia (ALL) or lymphoma. Two asymptomatic young women treated for ALL had falx meningiomas. White matter changes, low intensity foci (representing calcification or old haemorrhage) and heterogeneous intensity focic old haemorrhages) were seen only in patients who had undergone radiotherapy. Because of the possibility of benign, potentially curable brain tumours occurring after cranial irradiation, it may be wise to carry out occasional cranial imaging in the follow-up of these patients. No routine imaging follow-up is needed after chemotherapy alone.
我们对43名童年癌症幸存者进行了磁共振成像（MRI）检查，这些幸存者接受了不同的治疗方案，包括有或没有进行颅脑放疗。他们已无疾病，治疗在2至20年前就已停止。治疗针对的是各种恶性肿瘤，不包括脑肿瘤；27人因急性淋巴细胞白血病（ALL）或淋巴瘤接受了颅脑照射。两名接受ALL治疗的无症状年轻女性患有大脑镰脑膜瘤。仅在接受过放疗的患者中发现了白质改变、低强度病灶（代表钙化或陈旧性出血）和不均匀强度病灶（陈旧性出血）。由于颅脑照射后可能出现良性、潜在可治愈的脑肿瘤，因此在这些患者的随访中偶尔进行颅脑成像可能是明智的。单纯化疗后无需进行常规成像随访。
