Sakamoto M, Akazawa K, Nishioka Y, Sanui H, Inomata H, Nose Y
Department of Medical Informatics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Ophthalmology. 1995 Feb;102(2):317-21. doi: 10.1016/s0161-6420(95)31022-6.
Behçet disease is a chronic, recurrent, inflammatory disorder characterized by the triad of oral and genital ulcers and ocular lesions. The etiology is unknown. Although many of these patients become blind, some have good vision all their life.
To attain more accurate data on the prognosis of these patients, the authors studied 52 Japanese patients (101 eyes) seen at Kyushu University Hospital between 1980 and 1990. At the first visit, patients ranged in age from 21 to 61 years; at onset, they ranged in age from 17 to 55 years; and the disease duration at first visit was from 0 to 22 years. Thirty-five of the 101 eyes had a visual loss of more than five lines or the patients became blind. The authors divided the subjects into two groups--favorable group and unfavorable group. If an eye had more than five lines of visual loss or the patient became blind 3 years after the first visit, it was placed in the unfavorable group, and if not, it was classed in the favorable group. Thirty-two factors determined from clinical records were used to select statistically significant risk factors for visual loss, using univariate analysis and multivariate logistic regression analysis.
Univariate analysis showed the following four factors that were significantly different between favorable and unfavorable groups: sex, disease interval, other complications, and skin lesions (first year). Multivariate analysis showed that the following seven factors had mutually independent contributions to visual loss: skin lesions; arthritis; posterior attacks; other complications (experienced), including gastrointestinal, vascular, and central nervous system lesions; female sex; disease interval; and anterior attacks. The first four factors have effects of losing vision, whereas the others are related to vision retention.
The authors find that skin lesions, arthritis, posterior attacks, and other complications are linked to loss of vision, whereas female sex, disease interval, and anterior attacks are related to retention of vision.
白塞病是一种慢性、复发性炎症性疾病，其特征为口腔和生殖器溃疡以及眼部病变三联征。病因不明。尽管这些患者中有许多人会失明，但有些人一生视力良好。
为了获得关于这些患者预后的更准确数据，作者研究了1980年至1990年间在九州大学医院就诊的52例日本患者（101只眼）。初诊时，患者年龄在21至61岁之间；发病时，年龄在17至55岁之间；初诊时病程为0至22年。101只眼中有35只视力下降超过5行或患者失明。作者将研究对象分为两组——预后良好组和预后不良组。如果一只眼在初诊后3年视力下降超过5行或患者失明，则归入预后不良组；如果没有，则归入预后良好组。从临床记录中确定的32个因素用于通过单因素分析和多因素逻辑回归分析选择视力丧失的统计学显著危险因素。
单因素分析显示，预后良好组和预后不良组之间有以下四个因素存在显著差异：性别、疾病间隔、其他并发症和皮肤病变（第一年）。多因素分析显示，以下七个因素对视力丧失有相互独立的影响：皮肤病变；关节炎；后部发作；其他并发症（有经历过的），包括胃肠道、血管和中枢神经系统病变；女性；疾病间隔；前部发作。前四个因素有致视力丧失的作用，而其他因素与视力保留有关。
作者发现皮肤病变、关节炎、后部发作和其他并发症与视力丧失有关，而女性、疾病间隔和前部发作与视力保留有关。
