De Saedeleer V, Wechsung E, Houvenaghel A
Laboratory of Veterinary Physiology, State University Centre of Antwerp.
Prostaglandins Leukot Essent Fatty Acids. 1991 Jun;43(2):71-6. doi: 10.1016/0952-3278(91)90174-4.
In 5 conscious piglets with implanted electrodes in the antrum pylori, duodenum, jejunum and ileum, electromyographic activity was recorded daily on a multichannel recorder with a time constant of 0.03 s for intestinal and of 1 s for gastric recordings, and simultaneously integrated at 20 s intervals. PGE2 was infused for 2 h in relatively low doses of 0.1 and 1 microgram/kg/min, to avoid excessive hypersecretion, which would disguise direct effects. Each dose was tested once in each animal with a 1 week interval. Infusion of 0.1 microgram/kg/min revealed no significant changes in antral and small intestinal electrical activity. One microgram/kg/min however induced a strong depression of fast oscillations until the end of the infusion and prolongation of the inhibitory phase in the antrum following a duodenal phase of regular spiking activity. Intestinal segments displayed a prolongation of the quiescent phase and a decrease in the integrated area curve of the phase of irregular spiking activity. Recurrence of the phase of regular spiking activity was unaltered in either segment. These data suggest that the direct effect of PGE2 on gastrointestinal motility in the piglet is a partial inhibition of intestinal contractions.
在5只幽门窦、十二指肠、空肠和回肠植入电极的清醒仔猪中，每天使用时间常数为0.03秒（用于肠道记录）和1秒（用于胃部记录）的多通道记录仪记录肌电活动，并同时以20秒的间隔进行积分。以0.1和1微克/千克/分钟的相对低剂量输注PGE2 2小时，以避免过度分泌，否则会掩盖直接效应。每种剂量在每只动物中测试一次，间隔1周。输注0.1微克/千克/分钟时，胃窦和小肠电活动无明显变化。然而，1微克/千克/分钟会导致快速振荡强烈抑制直至输注结束，并在十二指肠出现规则尖峰活动的阶段后，胃窦抑制期延长。肠段显示静止期延长，不规则尖峰活动期的积分面积曲线下降。两个肠段中规则尖峰活动期的复发均未改变。这些数据表明，PGE2对仔猪胃肠动力的直接作用是部分抑制肠道收缩。
