Sachon C, Grimaldi A, Bosquet F, Croisier G, Thervet F, Vauthier D, Sebacher J, Darbois Y, Janse-Marec J, Pathier D
Service de Diabétologie-Métabolisme, Groupe Hospitalier Pitié-Salpêtrière, Paris.
Ann Med Interne (Paris). 1994;145(6):391-7.
A total of 212 diabetic pregnancies were studied prospectively over the period 1985 to 1986, included: 76 insulinodependent diabetics (IDD), 34 non insulinodependent diabetics (NIDD), and 102 gestational diabetes. The perinatal mortality rate for all diabetic pregnancies was 1.4% (n = 3); 3 congenital malformations were recorded (a therapeutic abortion was performed in 2 cases). These results are comparable with those of the non diabetic population. However, it is to be noticed that maternal as well as neonatal morbidity was important (hypoglycaemic comas: 18 in 9 IDD, preeclampsia: 7 IDD, 2 NIDD, 1 DG; caesarean delivery: 50% IDD, 50% NIDD, 25% DG; neonatal morbidity 20% of the new born. The main objectives must be targeted on the prevention of severe hypoglycaemia in IDD, the early diagnosis of DG and the development of pregnancy care in NIDD.
1985年至1986年期间，对总共212例糖尿病孕妇进行了前瞻性研究，其中包括：76例胰岛素依赖型糖尿病患者（IDD）、34例非胰岛素依赖型糖尿病患者（NIDD）和102例妊娠期糖尿病患者。所有糖尿病孕妇的围产期死亡率为1.4%（n = 3）；记录到3例先天性畸形（2例行治疗性流产）。这些结果与非糖尿病人群的结果相当。然而，需要注意的是，孕产妇和新生儿发病率都很高（低血糖昏迷：9例IDD中有18例，先兆子痫：7例IDD、2例NIDD、1例妊娠期糖尿病；剖宫产：50%的IDD、50%的NIDD、25%的妊娠期糖尿病；新生儿发病率为新生儿的20%）。主要目标必须针对预防IDD中的严重低血糖、妊娠期糖尿病的早期诊断以及NIDD中孕期护理的发展。
