Lukács G, Dobi S, Szabó M
Acta Hepatogastroenterol (Stuttg). 1978 Jun;25(3):238-42.
The authors make a case report of a male patient, 58 of age, whose complaints started 37 years ago; inspite of an operation, repeated medical check-ups and treatment, they had no other choice but to perform a further laparotomy when the patient presented himself with progressive cachexia and signs of an acute abdomen. Taking the history, the operative and histological findings of the patient into consideration, the correct diagnosis could be made: Whipple's disease. The presence of this condition was also proven by postoperative X-rays and immunological examinations. The patient has been restored to health after a year's antibiotic treatment. An impaired defensive ability, mainly of the immune and macrophage system can be proven to exist in Whipple's disease. Two main tasks are essential: 1) to hold the patient under constant control and 2) to continue research with the aim of finding ways of immunocorrection.
作者报告了一例58岁男性患者的病例，其症状始于37年前；尽管接受了手术、反复体检和治疗，但当患者出现进行性恶病质和急腹症体征时，他们别无选择，只能再次进行剖腹手术。综合考虑患者的病史、手术及组织学检查结果，做出了正确诊断：惠普尔病。术后X线检查和免疫学检查也证实了该病的存在。经过一年的抗生素治疗，患者已康复。已证实惠普尔病存在防御能力受损，主要是免疫和巨噬细胞系统。有两项主要任务至关重要：1）持续对患者进行监测；2）继续开展研究，以寻找免疫纠正方法。
