Hupperets P S, Schutte B, van Assche C, Schouten L J, Jager J, de Jong J, Blijham G H
Department of Internal Medicine, Academic Hospital Maastricht, The Netherlands.
Breast Cancer Res Treat. 1994;32(2):197-202. doi: 10.1007/BF00665770.
Ninety-one cases of primary breast cancers and their nodal metastases were examined with DNA flow cytometry. No differences were found between the stemline distributions in the primary tumors and nodal metastases. At both sites stemlines clustered around a DNA index of 1.0 (33-40% of cases) and 1.8. The mean S-phase fractions were 7.9 in primary tumors versus 5.6% in nodal metastases (p = 0.02); this difference was also observed if the analysis was restricted to cases with DNA aneuploidy at both sites (10.2 versus 7.6%, p = 0.04). Our results indicate that axillary nodal ploidy and proliferation reflect primary tumor characteristics rather than displaying changes associated with selection during the lymphatic metastatic process. Lymph nodes may have a suppressive effect on the proliferation of tumor cells.
对91例原发性乳腺癌及其淋巴结转移灶进行了DNA流式细胞术检测。原发性肿瘤和淋巴结转移灶的干系分布无差异。在两个部位，干系均聚集在DNA指数1.0（33 - 40%的病例）和1.8左右。原发性肿瘤的平均S期分数为7.9%，而淋巴结转移灶为5.6%（p = 0.02）；如果分析仅限于两个部位均为DNA非整倍体的病例，也观察到了这种差异（10.2%对7.6%，p = 0.04）。我们的结果表明，腋窝淋巴结的倍性和增殖反映了原发性肿瘤的特征，而不是显示与淋巴转移过程中的选择相关的变化。淋巴结可能对肿瘤细胞的增殖有抑制作用。
