Kobayashi H, Sunaga R, Furihata K, Morisaki N, Iwasaki S
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
J Antibiot (Tokyo). 1995 Jan;48(1):42-52. doi: 10.7164/antibiotics.48.42.
A new antifungal antibiotic, fusarielin A, and three related compounds, fusarielins B, C and D, were obtained from a culture of a Fusarium sp. The skeletal structure and the relative stereochemistry of fusarielin A were determined mainly on the basis of its NMR data, and the absolute structure was elucidated by using the exciton chirality method and the modified Mosher method. The structures of the other homologues were determined by comparison of their spectral data with those of fusarielin A.
从一种镰刀菌属真菌的培养物中获得了一种新型抗真菌抗生素——镰孢菌素A以及三种相关化合物，即镰孢菌素B、C和D。镰孢菌素A的骨架结构和相对立体化学主要基于其核磁共振（NMR）数据确定，其绝对结构通过激子手性法和改良的莫舍尔法得以阐明。其他同系物的结构则通过将它们的光谱数据与镰孢菌素A的光谱数据进行比较来确定。
