白细胞介素-15对人血T淋巴细胞的化学趋化作用。
Chemoattraction of human blood T lymphocytes by interleukin-15.
作者信息
Wilkinson P C, Liew F Y
机构信息
Department of Immunology, University of Glasgow, Western Infirmary, United Kingdom.
出版信息
J Exp Med. 1995 Mar 1;181(3):1255-9. doi: 10.1084/jem.181.3.1255.
Abstract
Recombinant interleukin (IL)-15, derived from a simian kidney epithelial cell line, is a chemoattractant for human blood T lymphocytes judged by its ability to increase the proportion of cells in polarized morphology, to stimulate invasion of collagen gels containing IL-15, and to increase the proportion of locomotor cells observed by time-lapse videorecording. The ability of lymphocytes to respond was partly, but not completely, inhibited by pretreatment with anti-IL-2 receptor beta-chain. The activity of IL-15 was completely abolished by preincubation with aIL-15 but unaffected by preincubation with aIL-2. No response of monocytes, neutrophils, or B lymphocytes to IL-15 was observed.
摘要
从猴肾上皮细胞系衍生而来的重组白细胞介素（IL）-15，通过以下能力判断，它是人类血液T淋巴细胞的化学引诱剂：增加呈极化形态的细胞比例、刺激含有IL-15的胶原凝胶的侵袭，以及通过延时录像观察增加运动细胞的比例。淋巴细胞的反应能力部分但并非完全受到抗IL-2受体β链预处理的抑制。IL-15的活性通过与抗IL-15预孵育而完全消除，但不受与抗IL-2预孵育的影响。未观察到单核细胞、中性粒细胞或B淋巴细胞对IL-15有反应。
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