静脉注射免疫球蛋白疗法成功治疗有症状的IgG3缺乏症。
Symptomatic IgG3 deficiency successfully treated with intravenous immunoglobulin therapy.
作者信息
Snowden J A, Milford-Ward A, Reilly J T
机构信息
Northern General Hospital, Sheffield, UK.
出版信息
Postgrad Med J. 1994 Dec;70(830):924-6. doi: 10.1136/pgmj.70.830.924.
Abstract
We report the case of a 35 year old female who presented with an 8 year history of repeated upper respiratory tract infection, lymphadenopathy and sinusitis associated with IgG3 deficiency. Courses of monthly intravenous immunoglobulin therapy (0.4 g/kg) resulted in a dramatic clinical improvement on three different occasions. We suggest that investigation of adults with features of immunosuppression, despite normal levels of total IgG, should include IgG3 subclass analysis and that symptomatic patients should be given a trial of immunoglobulin replacement therapy.
摘要
我们报告了一例35岁女性病例，该患者有8年反复上呼吸道感染、淋巴结病和鼻窦炎病史，伴有IgG3缺乏。每月静脉注射免疫球蛋白治疗（0.4 g/kg）疗程在三个不同时间点均带来了显著的临床改善。我们建议，对于具有免疫抑制特征的成年人，尽管总IgG水平正常，其检查应包括IgG3亚类分析，且有症状的患者应试行免疫球蛋白替代治疗。
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