Olinder-Nielsen Ann-Margreth, Granert Carl, Forsberg Pia, Friman Vanda, Vietorisz Auli, Björkander Janne
Department of Infectious Diseases, County Hospital Ryhov, Jönköping, Sweden.
Scand J Infect Dis. 2007;39(1):44-50. doi: 10.1080/00365540600951192.
350 adult patients in Sweden were included in a retrospective study covering more than 2000 patient-y, to evaluate the efficacy of immunoglobulin (Ig) prophylaxis. All patients had selective or combined IgG subclass deficiency, without IgA deficiency, and suffered from recurrent respiratory tract infections (RTIs). The patients had been given Ig prophylaxis for 0.5-21 y (mean 5.5 y). In total, 164/350 of the patients had a concomitant lung disease. Because of the heterogeneity of this retrospective material we evaluated only those patients with 4 or more antibiotic-demanding (i.e. presumably bacterial) episodes of RTI per y treated with an Ig dose of about 100 mg/kg/week (132/350). The frequency of antibiotic treated RTIs prior to and during latest y/s of Ig prophylaxis was compared. No difference in response could be found between patients with and without chronic lung diseases. In 92/132 a > or = 50% reduction of the rate of episodes of antibiotic-demanding RTIs was recorded (p < 0.001). The overall reduction of the RTI frequency was for IgG1 57%, IgG2 59%, IgG3 63% and for the combinations 61% (all p<0.001).
瑞典的350名成年患者被纳入一项回顾性研究，该研究涵盖超过2000患者年，以评估免疫球蛋白（Ig）预防的疗效。所有患者均有选择性或合并IgG亚类缺陷，无IgA缺陷，并患有复发性呼吸道感染（RTI）。这些患者接受Ig预防治疗0.5 - 21年（平均5.5年）。总共350名患者中有164名患有合并肺部疾病。由于该回顾性资料的异质性，我们仅评估了那些每年有4次或更多次需要使用抗生素（即可能为细菌性）的RTI发作且接受约100mg/kg/周Ig剂量治疗的患者（132/350）。比较了在Ig预防治疗的最后一年之前和期间接受抗生素治疗的RTI频率。有慢性肺部疾病和无慢性肺部疾病的患者在反应上未发现差异。在132名患者中有92名（92/132）记录到需要使用抗生素的RTI发作率降低了≥50%（p < 0.001）。RTI频率的总体降低情况为：IgG1降低57%，IgG2降低59%，IgG3降低63%，联合使用时降低61%（所有p < 0.001）。
