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酿酒酵母中DNA损伤诱导诱变所需功能基因REV7的克隆与序列分析

Cloning and sequence of REV7, a gene whose function is required for DNA damage-induced mutagenesis in Saccharomyces cerevisiae.

作者信息

Torpey L E, Gibbs P E, Nelson J, Lawrence C W

机构信息

Department of Biophysics, University of Rochester School of Medicine and Dentistry, NY 14642.

出版信息

Yeast. 1994 Nov;10(11):1503-9. doi: 10.1002/yea.320101115.

DOI:10.1002/yea.320101115
PMID:7871890
Abstract

The function of the REV7 gene is required for DNA damage-induced mutagenesis in budding yeast, Saccharomyces cerevisiae, and is therefore thought to promote replication past sites of mutagen damage in the DNA template. We have cloned this gene by complementation of the rev7-2 mutant defect, and determined its sequence. REV7 encodes a predicted protein of M(r) 28,759 which is unlikely any other protein in the NCBI non-redundant protein sequence data base, and which is inessential for viability.

摘要

酿酒酵母中，REV7基因的功能是DNA损伤诱导的诱变所必需的，因此被认为可促进越过DNA模板中诱变损伤位点的复制。我们通过互补rev7-2突变体缺陷克隆了该基因，并确定了其序列。REV7编码一种预测的分子量为28,759的蛋白质，该蛋白质与NCBI非冗余蛋白质序列数据库中的任何其他蛋白质都不太可能相同，并且对于细胞生存力并非必需。

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