Nitta H, Matsumoto K, Shimizu M, Ni X H, Watanabe H
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines, Toyama, Japan.
Biol Pharm Bull. 1995 Oct;18(10):1439-42. doi: 10.1248/bpb.18.1439.
The effects of Panax ginseng ethanol extract and its water (WSF)- and lipid-soluble (LSF) fractions on the scopolamine-induced disruption of radial maze performance in rats were examined. Ginseng root was refluxed with ethanol, and WSF and LSF were prepared from this ethanol extract. Scopolamine (0.075-0.3 mg/kg, i.p.) dose-dependently impaired the maze performance. However, the oral administration of Panax ginseng ethanol extract and WSF (2-8 g dried root/kg) 90 min before testing improved the maze performance disrupted by scopolamine (0.3 mg/kg) in a dose-dependent manner, but LSF failed to attenuate the disruption. These data suggest that ginseng extract possesses a beneficial effect regarding spatial cognitive impairment and that the water-soluble fraction of ginseng extract mainly contributes to the effect of the ethanol extract.
研究了人参乙醇提取物及其水溶性（WSF）和脂溶性（LSF）组分对东莨菪碱诱导的大鼠放射状迷宫行为障碍的影响。人参根用乙醇回流提取，从该乙醇提取物中制备WSF和LSF。东莨菪碱（0.075 - 0.3mg/kg，腹腔注射）剂量依赖性地损害迷宫行为。然而，在测试前90分钟口服人参乙醇提取物和WSF（2 - 8g干燥根/kg）以剂量依赖性方式改善了由东莨菪碱（0.3mg/kg）破坏的迷宫行为，但LSF未能减轻这种破坏。这些数据表明人参提取物对空间认知障碍具有有益作用，并且人参提取物的水溶性组分主要促成乙醇提取物的这种作用。
