药物性肺炎的一种有用诊断方法：病例报告

A useful diagnostic method for drug-induced pneumonitis: a case report.

作者信息

Kawasaki A, Mizushima Y, Kunitani H, Kitagawa M, Kobayashi M

机构信息

First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.

出版信息

Am J Chin Med. 1994;22(3-4):329-36. doi: 10.1142/S0192415X94000395.

DOI:10.1142/S0192415X94000395

PMID:7872245

Abstract

A 51 year-old male was admitted to our hospital with chief complaints of fever, dry cough and dyspnea. Chest X-ray films and his history of taking Chinese medicine for liver dysfunction were suggestive of drug-induced pneumonitis. Lymphocyte stimulation test (LST) to causative Chinese medical drugs of Sho-saiko-to and Dai-saiko-to was negative with peripheral blood lymphocytes (PBL), but was positive with lymphocytes from bronchoalveolar lavage fluid (BALF). In vivo challenge test for Sho-saiko-to was positive. The LST with BALF-lymphocytes proved to be very useful in making a diagnosis of drug-induced pneumonitis.

摘要

一名51岁男性因发热、干咳和呼吸困难为主诉入院。胸部X光片及他因肝功能不全服用中药的病史提示药物性肺炎。对小柴胡汤和大柴胡汤等致病因中药进行的淋巴细胞刺激试验（LST），外周血淋巴细胞（PBL）结果为阴性，但支气管肺泡灌洗 fluid（BALF）中的淋巴细胞结果为阳性。小柴胡汤的体内激发试验为阳性。BALF淋巴细胞的LST被证明在药物性肺炎的诊断中非常有用。