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乙胺丁醇、异烟肼、卡那霉素、利福平及链霉素对鸟分枝杆菌-胞内分枝杆菌复合体的体外协同活性

In vitro synergistic activity of ethambutol, isoniazid, kanamycin, rifampin, and streptomycin against Mycobacterium avium-intracellulare complex.

作者信息

Zimmer B L, DeYoung D R, Roberts G D

出版信息

Antimicrob Agents Chemother. 1982 Jul;22(1):148-50. doi: 10.1128/AAC.22.1.148.

DOI:10.1128/AAC.22.1.148
PMID:7125626
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC183690/
Abstract

Strains of Mycobacterium avium-intracellulare complex often exhibit in vitro resistance to common antimycobacterial agents. Combinations of etambutol, isoniazid, kanamycin, rifampin, and streptomycin were tested to determine if synergism occurred. Ninety-six percent of the strains were susceptible to a combination of ethambutol and rifampin at concentrations attainable clinically. Other combinations of antimycobacterial agents inhibited 4 to 82% of the isolates tested.

摘要

鸟分枝杆菌-胞内分枝杆菌复合群菌株通常在体外对常见抗分枝杆菌药物表现出耐药性。对乙胺丁醇、异烟肼、卡那霉素、利福平和链霉素的组合进行了测试，以确定是否存在协同作用。96%的菌株对临床上可达到的乙胺丁醇和利福平组合敏感。其他抗分枝杆菌药物组合抑制了4%至82%的测试分离株。

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In vitro synergistic activity of ethambutol, isoniazid, kanamycin, rifampin, and streptomycin against Mycobacterium avium-intracellulare complex.乙胺丁醇、异烟肼、卡那霉素、利福平及链霉素对鸟分枝杆菌-胞内分枝杆菌复合体的体外协同活性
Antimicrob Agents Chemother. 1982 Jul;22(1):148-50. doi: 10.1128/AAC.22.1.148.
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本文引用的文献

1
Rifampin: in vitro effect on atypical mycobacteria.利福平：对非结核分枝杆菌的体外作用。
Am Rev Respir Dis. 1971 Aug;104(2):272-4. doi: 10.1164/arrd.1971.104.2.272.
2
New approach for the evaluation of antimycobacterial drug combinations in vitro (the laboratory model man).体外评估抗分枝杆菌药物组合的新方法（实验室模型人）。
Appl Microbiol. 1969 Sep;18(3):399-403. doi: 10.1128/am.18.3.399-403.1969.
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Influence of the medium on the in vitro susceptibility of Mycobacterium tuberculosis to ethambutol.培养基对结核分枝杆菌体外乙胺丁醇敏感性的影响。
Am Rev Respir Dis. 1970 Oct;102(4):653-5. doi: 10.1164/arrd.1970.102.4.653.
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[Sensitivities of atypical mycobacteria to various drugs. III. Sensitivities of M. intracellulare to antituberculous drugs in triple combinations (author's transl)].非典型分枝杆菌对各种药物的敏感性。III. 细胞内分枝杆菌对三联抗结核药物的敏感性（作者译）
Kekkaku. 1977 Jul;52(7):331-8.
5
The relative drug susceptibility of opaque colonial forms of Mycobacterium intracellulare-avium: does it affect therapeutic results?胞内鸟分枝杆菌不透明菌落形态的相对药物敏感性：它会影响治疗结果吗？
Am Rev Respir Dis. 1978 Jun;117(6):1142-3. doi: 10.1164/arrd.1978.117.6.1142.
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Long-term results of medical treatment in Mycobacterium intracellulare infection.胞内分枝杆菌感染的药物治疗长期结果
Am J Med. 1979 Sep;67(3):449-53. doi: 10.1016/0002-9343(79)90792-7.
7
Pulmonary mycobacterial infections due to Mycobacterium intracellulare-avium complex. Clinical features and course in 100 consecutive cases.鸟分枝杆菌胞内菌复合群所致肺部分枝杆菌感染。100例连续病例的临床特征及病程
Chest. 1979 Feb;75(2):115-9. doi: 10.1378/chest.75.2.115.
8
Antimicrobial synergism--an elusive concept.抗菌协同作用——一个难以捉摸的概念。
J Infect Dis. 1979 Oct;140(4):639-41. doi: 10.1093/infdis/140.4.639.
9
Comparison of techniques for measurement of in vitro antibiotic synergism.体外抗生素协同作用测量技术的比较。
J Infect Dis. 1979 Oct;140(4):629-33. doi: 10.1093/infdis/140.4.629.
10
Identification of clinical isolates of mycobacteria with gas-liquid chromatography alone.仅用气液色谱法鉴定分枝杆菌的临床分离株。
J Clin Microbiol. 1979 Oct;10(4):506-14. doi: 10.1128/jcm.10.4.506-514.1979.