乙胺丁醇、异烟肼、卡那霉素、利福平及链霉素对鸟分枝杆菌-胞内分枝杆菌复合体的体外协同活性
In vitro synergistic activity of ethambutol, isoniazid, kanamycin, rifampin, and streptomycin against Mycobacterium avium-intracellulare complex.
作者信息
Zimmer B L, DeYoung D R, Roberts G D
出版信息
Antimicrob Agents Chemother. 1982 Jul;22(1):148-50. doi: 10.1128/AAC.22.1.148.
Abstract
Strains of Mycobacterium avium-intracellulare complex often exhibit in vitro resistance to common antimycobacterial agents. Combinations of etambutol, isoniazid, kanamycin, rifampin, and streptomycin were tested to determine if synergism occurred. Ninety-six percent of the strains were susceptible to a combination of ethambutol and rifampin at concentrations attainable clinically. Other combinations of antimycobacterial agents inhibited 4 to 82% of the isolates tested.
摘要
鸟分枝杆菌-胞内分枝杆菌复合群菌株通常在体外对常见抗分枝杆菌药物表现出耐药性。对乙胺丁醇、异烟肼、卡那霉素、利福平和链霉素的组合进行了测试，以确定是否存在协同作用。96%的菌株对临床上可达到的乙胺丁醇和利福平组合敏感。其他抗分枝杆菌药物组合抑制了4%至82%的测试分离株。
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