Higami Y, Yu B P, Shimokawa I, Bertrand H, Hubbard G B, Masoro E J
First Department of Pathology, Nagasaki University School of Medicine, Japan.
J Gerontol A Biol Sci Med Sci. 1995 Mar;50(2):B72-7. doi: 10.1093/gerona/50a.2.b72.
The effects of dietary restriction (DR) on spontaneous oncogenesis in male Fischer 344 rats were analyzed. Previously reported analyses of studies carried out in our laboratory demonstrated that DR reduces the incidence and delays the onset, but not the progression, of leukemia in male F344 rats. In this report, the influence of DR on pituitary tumors, adrenal pheochromocytoma, pancreatic islet cell tumors, and interstitial cell tumors of the testis was analyzed. DR reduced the relative incidence (relative onset rates) and delayed the onset of the four tumors. DR also retarded the progression (duration from onset to death) of pituitary tumors and pheochromocytoma. DR has delayed the onset of all tumors of the male F344 rat so far analyzed, but its effect on tumor progression appears to be lesion-dependent.
分析了饮食限制（DR）对雄性Fischer 344大鼠自发肿瘤发生的影响。此前在我们实验室进行的研究分析表明，饮食限制可降低雄性F344大鼠白血病的发病率并延迟其发病，但不影响白血病的进展。在本报告中，分析了饮食限制对垂体肿瘤、肾上腺嗜铬细胞瘤、胰岛细胞瘤和睾丸间质细胞瘤的影响。饮食限制降低了这四种肿瘤的相对发病率（相对发病几率）并延迟了其发病。饮食限制还延缓了垂体肿瘤和嗜铬细胞瘤的进展（从发病到死亡的持续时间）。饮食限制已延迟了迄今为止所分析的雄性F344大鼠所有肿瘤的发病，但它对肿瘤进展的影响似乎取决于病变情况。
