衰老与雷帕霉素靶蛋白（TOR）：交织于生命之网。
Aging and TOR: interwoven in the fabric of life.
作者信息
Sharp Zelton Dave
机构信息
Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center San Antonio, San Antonio, TX, 78245, USA.
出版信息
Cell Mol Life Sci. 2011 Feb;68(4):587-97. doi: 10.1007/s00018-010-0542-0. Epub 2010 Oct 21.
Abstract
Longstanding results with calorie and growth factor restriction plus recent results with the first interventional drug suggest that retarding the pace of aging to improve the quality of life of older people is at hand. The biological system targeted by these approaches is the target of rapamycin (TOR), which is central for cellular responses to a variety of stimuli including stressors, growth factors, and nutrients and energy states. That the life-extending response to reducing its activity is highly conserved from yeast to mammals is consistent with the evolution of aging as a strategy to preserve reproductive potential of young cells and animals.
摘要
长期以来热量和生长因子限制的研究成果，加上首款干预性药物的最新研究成果表明，延缓衰老速度以改善老年人生活质量已近在咫尺。这些方法所针对的生物系统是雷帕霉素靶蛋白（TOR），它对于细胞对包括应激源、生长因子、营养物质和能量状态在内的多种刺激的反应至关重要。从酵母到哺乳动物，降低其活性所产生的延长寿命反应高度保守，这与衰老作为一种保护年轻细胞和动物生殖潜力的策略的进化是一致的。
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本文引用的文献
1
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201. doi: 10.1093/gerona/glq178. Epub 2010 Oct 25.
2
Segregation of yeast nuclear pores.
Nature. 2010 Jul 22;466(7305):E1. doi: 10.1038/nature09255.
3
Altruistic colony defense by menopausal female insects.
Curr Biol. 2010 Jul 13;20(13):1182-6. doi: 10.1016/j.cub.2010.04.057. Epub 2010 Jun 17.
4
Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase.
Nat Biotechnol. 2010 Jul;28(7):738-42. doi: 10.1038/nbt.1645. Epub 2010 Jun 27.
5
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs.
Science. 2010 May 28;328(5982):1172-6. doi: 10.1126/science.1187532.
6
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.
Cell Metab. 2010 May 5;11(5):390-401. doi: 10.1016/j.cmet.2010.03.014.
7
Lysosomal Rag-ulation of mTOR complex 1 activity.
Cell Metab. 2010 May 5;11(5):341-2. doi: 10.1016/j.cmet.2010.04.010.
8
Rapamycin and quasi-programmed aging: four years later.
Cell Cycle. 2010 May 15;9(10):1859-62. doi: 10.4161/cc.9.10.11872.
9
Extending healthy life span--from yeast to humans.
Science. 2010 Apr 16;328(5976):321-6. doi: 10.1126/science.1172539.
10
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr 8.
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