Vijay V, Snehalatha C, Ramachandran A, Viswanathan M
Dept of Biochemistry, Diabetes Research Centre, Royapuram, Madras.
J Assoc Physicians India. 1994 Oct;42(10):792-4.
Proteinuria was estimated in 600 non-insulin dependent diabetes mellitus (NIDDM) patients in 24 hrs collection of urine. The test was repeated at least twice in a year to confirm the persistence of proteinuria. Mild proteinuria (200-500 mg/d) occurred in 94 (15.7%) and nephropathy (> 500 mg/d) in 112 (18.7%) patients. Nephropathy commonly occurred with long-standing diabetes (> 10 years). Development of proteinuria correlated directly with the duration of diabetes, diastolic and systolic blood pressure, age of the patients, serum creatinine and inversely with creatinine clearance. Retinopathy was seen in 75% of those with nephropathy. It is concluded that proteinuria occurs in one third of NIDDM patients and the risk of nephropathy increases with duration of disease.
对600例非胰岛素依赖型糖尿病（NIDDM）患者进行了24小时尿蛋白定量检测。该检测每年至少重复两次以确认蛋白尿的持续性。94例（15.7%）患者出现轻度蛋白尿（200 - 500mg/d），112例（18.7%）患者出现肾病（>500mg/d）。肾病常见于病程较长（>10年）的糖尿病患者。蛋白尿的发生与糖尿病病程、舒张压和收缩压、患者年龄、血清肌酐直接相关，与肌酐清除率呈负相关。75%的肾病患者有视网膜病变。结论是，三分之一的NIDDM患者会出现蛋白尿，肾病风险随病程延长而增加。
