Andrieu J M, Lu W, Levy R
Laboratoire d'Immunologie des Tumeurs, Hôpital Laënnec, Faculté de Médecine Necker, Université René Descartes, Paris, France.
J Infect Dis. 1995 Mar;171(3):523-30. doi: 10.1093/infdis/171.3.523.
Forty-four asymptomatic patients infected with human immunodeficiency virus type 1 (HIV-1), who had 200-799 CD4 cells/microL, received oral prednisolone (0.5 mg/kg for 6 months; 0.3 mg/kg thereafter). After 1 year of treatment, no major side effect or AIDS events had occurred. The percentage of DR+ and CD25+ phenotypes in CD4 T cells decreased significantly as did levels of serum IgG, IgA, and beta 2-microglobulin. Serum p24 antigen and HIV RNA levels remained stable. CD4 cell counts increased significantly at all time points (median increase at 1 year, 119 cells/microL). Peripheral blood mononuclear cell apoptosis after overnight stimulation with anti-CD3 monoclonal antibodies was strongly inhibited at all times. In asymptomatic seropositive patients, immunotherapy for 1 year with glucocorticoids was safe and led to sustained increases in CD4 cell counts and to improvement or stabilization of other biologic markers of disease activity.
44例感染1型人类免疫缺陷病毒（HIV-1）且CD4细胞计数为200 - 799个/微升的无症状患者，接受口服泼尼松龙治疗（0.5毫克/千克，持续6个月；之后为0.3毫克/千克）。治疗1年后，未发生重大副作用或艾滋病相关事件。CD4 T细胞中DR+和CD25+表型的百分比显著下降，血清IgG、IgA和β2-微球蛋白水平也显著下降。血清p24抗原和HIV RNA水平保持稳定。所有时间点的CD4细胞计数均显著增加（1年时中位数增加119个/微升）。用抗CD3单克隆抗体过夜刺激后，外周血单个核细胞凋亡在所有时间均受到强烈抑制。在无症状血清阳性患者中，糖皮质激素免疫治疗1年是安全的，可使CD4细胞计数持续增加，并改善或稳定疾病活动的其他生物学指标。
