Amend N K, Loeffler D G, Ward B C, Van Hoosier G L
Lab Anim Sci. 1976 Aug;26(4):566-72.
Twenty-six of 39 Syrian hamsters obtained by this laboratory from a pet supplier had enteritis and showed signs of "wet tail." An enteritis was reproduced in healthy hamsters by oral inoculation of homogenized ilea and jejuna from the diseased hamsters. The most characteristic pathologicfeatures were a variably enlarged distal jejunum and ileum and granulomatous lesions in the ileal subserosal wall. Histologic findings included a greatly hyperplastic jejunal and ileal mucosa that frequently contained submucosal accumulations of inflammatory cells. Often mucosal glands extended into these areas. The gross and histologic lesions produced were identical to those described in proliferative ileitis. Bacterial cultures from infected tissues consistently grew a slow lactose-fermenting Escherichia coli. Although diarrhea could be produced by oral inoculation of the organism, the typical morphologic lesions were not produced.
本实验室从一家宠物供应商处获得的39只叙利亚仓鼠中，有26只患有肠炎，并表现出“湿尾”症状。通过口服接种患病仓鼠的回肠和空肠匀浆，在健康仓鼠中复制出了肠炎。最典型的病理特征是远端空肠和回肠不同程度地扩张，以及回肠浆膜下层出现肉芽肿性病变。组织学检查结果包括空肠和回肠黏膜大量增生，黏膜下常有炎性细胞聚集。黏膜腺常延伸至这些区域。所产生的大体和组织学病变与增生性回肠炎中描述的病变相同。感染组织的细菌培养始终能培养出一种缓慢发酵乳糖的大肠杆菌。虽然口服接种该菌可导致腹泻，但并未产生典型的形态学病变。
