Díez J J, Doforno R A, Iglesias P, Sastre J, Gómez-Pan A, Borbujo J
Department of Endocrinology, Hospital La Paz, Madrid, Spain.
J Clin Lab Immunol. 1993;40(3):125-34.
IgG and IgM anticardiolipin antibodies were assayed by an ELISA technique in 69 patients with autoimmune thyroid disease (ATD) and compared with 43 patients with thyroid disease of no autoimmune aetiology (non-ATD) and 72 healthy controls. IgG anticardiolipin antibodies were detectable in 3 of 41 patients with Graves' disease, in 4 of 28 patients with Hashimoto's thyroiditis, in 5 of 43 non-ATD patients and in 3 of 72 normal subjects (differences not significant). IgM antibodies were measurable in 3 patients with Graves' disease, in 1 patient with Hashimoto's thyroiditis, in 1 non-ATD patient and in 2 normal subjects (differences not significant). Patients with anticardiolipin antibodies did not exhibit a higher titre of thyroglobulin or thyroid microsomal antibodies than patients without anticardiolipin antibodies. There was no relation between IgG or IgM anticardiolipin antibody levels and the thyroid function status, the serum concentration of thyroid hormones or thyrotrophin levels. Neither was there any correlation between anticardiolipin antibody levels and age, sex, previous treatments or time of disease progress. Our results suggest that there is no association between anticardiolipin antibodies and ATD.
采用酶联免疫吸附测定（ELISA）技术检测了69例自身免疫性甲状腺疾病（ATD）患者的IgG和IgM抗心磷脂抗体，并与43例无自身免疫病因的甲状腺疾病患者（非ATD）和72例健康对照者进行了比较。在41例格雷夫斯病患者中有3例可检测到IgG抗心磷脂抗体，28例桥本甲状腺炎患者中有4例，43例非ATD患者中有5例，72例正常受试者中有3例（差异无统计学意义）。在3例格雷夫斯病患者、1例桥本甲状腺炎患者、1例非ATD患者和2例正常受试者中可检测到IgM抗体（差异无统计学意义）。有抗心磷脂抗体的患者与没有抗心磷脂抗体的患者相比，甲状腺球蛋白或甲状腺微粒体抗体滴度并未更高。IgG或IgM抗心磷脂抗体水平与甲状腺功能状态、甲状腺激素血清浓度或促甲状腺激素水平之间均无关联。抗心磷脂抗体水平与年龄、性别、既往治疗或疾病进展时间之间也无相关性。我们的结果表明，抗心磷脂抗体与ATD之间无关联。
