Stubbs M T, Bode W
Max-Planck Institut für Biochemie, Germany.
Trends Biochem Sci. 1995 Jan;20(1):23-8. doi: 10.1016/s0968-0004(00)88945-8.
Thrombin is the primary promoter of blood clotting; it also plays an important role in the regulation of the coagulation cascade and has been implicated in a number of other cellular processes. How can one molecule catalyse such a variety of events? The recent X-ray structure determination of human a-thrombin and related structures shows that the molecule can be divided into several functional regions that recognize different chemical moieties. By using different combinations of these elements, thrombin can interact with a variety of macromolecules with high specificity.
凝血酶是血液凝固的主要促进剂；它在凝血级联反应的调节中也起着重要作用，并且还涉及许多其他细胞过程。一个分子如何催化如此多种不同的事件呢？最近对人α-凝血酶的X射线结构测定及相关结构表明，该分子可分为几个识别不同化学基团的功能区域。通过使用这些元件的不同组合，凝血酶能够以高特异性与多种大分子相互作用。
