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脊椎动物mRNA翻译保真度和效率的决定因素。

Determinants of translational fidelity and efficiency in vertebrate mRNAs.

作者信息

Kozak M

机构信息

Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Piscataway 08854.

出版信息

Biochimie. 1994;76(9):815-21. doi: 10.1016/0300-9084(94)90182-1.

DOI:10.1016/0300-9084(94)90182-1
PMID:7880897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7125885/
Abstract

This article reviews current knowledge on the mechanisms affecting the fidelity of initiation codon selection, and discusses the effects of structural features in the 5′-non-coding region on the efficiency of translation of messenger RNA molecules.

摘要

本文综述了关于影响起始密码子选择准确性的机制的当前知识，并讨论了5′非编码区的结构特征对信使RNA分子翻译效率的影响。

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本文引用的文献

1
Translational repression of brlA expression prevents premature development in Aspergillus.
EMBO J. 1993 Jun;12(6):2449-57. doi: 10.1002/j.1460-2075.1993.tb05899.x.
2
Zinc finger-like motifs in rat ribosomal proteins S27 and S29.大鼠核糖体蛋白S27和S29中的锌指样基序。
Nucleic Acids Res. 1993 Feb 11;21(3):649-55. doi: 10.1093/nar/21.3.649.
3
Human gene mutations affecting RNA processing and translation.影响RNA加工和翻译的人类基因突变。
Ann Med. 1993 Feb;25(1):11-7. doi: 10.3109/07853899309147851.
4
Influence of the three nucleotides upstream of the initiation codon on expression of the Escherichia coli lacZ gene in Saccharomyces cerevisiae.起始密码子上游三个核苷酸对酿酒酵母中大肠杆菌lacZ基因表达的影响。
Nucleic Acids Res. 1993 Sep 11;21(18):4268-71. doi: 10.1093/nar/21.18.4268.
5
cis-acting elements in the 5'-untranslated region of rat testis proenkephalin mRNA regulate translation of the precursor protein.
J Biol Chem. 1993 Oct 15;268(29):22164-9.
6
Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.一种新的哺乳动物丝裂原活化蛋白激酶激酶MKK2的鉴定与特性分析
Mol Cell Biol. 1993 Aug;13(8):4539-48. doi: 10.1128/mcb.13.8.4539-4548.1993.
7
La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate.自身抗原增强并纠正了脊髓灰质炎病毒RNA在网织红细胞裂解物中的异常翻译。
J Virol. 1993 Jul;67(7):3798-807. doi: 10.1128/JVI.67.7.3798-3807.1993.
8
A small highly basic protein is encoded in overlapping frame within the P gene of vesicular stomatitis virus.一种小的高碱性蛋白在水疱性口炎病毒P基因内的重叠阅读框中编码。
J Virol. 1993 Jun;67(6):3103-10. doi: 10.1128/JVI.67.6.3103-3110.1993.
9
Translation of equine infectious anemia virus bicistronic tat-rev mRNA requires leaky ribosome scanning of the tat CTG initiation codon.马传染性贫血病毒双顺反子tat-rev mRNA的翻译需要对tat CTG起始密码子进行核糖体渗漏扫描。
J Virol. 1993 Mar;67(3):1433-40. doi: 10.1128/JVI.67.3.1433-1440.1993.
10
CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials.CCAAT/增强子结合蛋白信使核糖核酸被翻译成具有不同转录激活潜能的多种蛋白质。
Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8219-23. doi: 10.1073/pnas.90.17.8219.