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Role of biopersistence in the pathogenicity of man-made fibers and methods for evaluating biopersistence: a summary of two round-table discussions.生物持久性在人造纤维致病性中的作用及生物持久性评估方法：两次圆桌讨论综述
Environ Health Perspect. 1994 Oct;102 Suppl 5(Suppl 5):277-83. doi: 10.1289/ehp.94102s5277.
2
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Significance of the biodurability of man-made vitreous fibers to risk assessment.人造玻璃纤维生物耐久性对风险评估的意义。
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Chronic inhalation toxicity of size-separated glass fibers in Fischer 344 rats.费希尔344大鼠中按尺寸分离的玻璃纤维的慢性吸入毒性
Fundam Appl Toxicol. 1993 May;20(4):464-76. doi: 10.1006/faat.1993.1057.
2
Significance of durability of mineral fibers for their toxicity and carcinogenic potency in the abdominal cavity of rats in comparison with the low sensitivity of inhalation studies.与吸入研究的低敏感性相比，矿物纤维在大鼠腹腔中的毒性和致癌潜力的持久性的意义。
Environ Health Perspect. 1994 Oct;102 Suppl 5(Suppl 5):145-50. doi: 10.1289/ehp.94102s5145.
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Relationship between lung biopersistence and biological effects of man-made vitreous fibers after chronic inhalation in rats.大鼠慢性吸入人造玻璃纤维后肺生物持久性与生物学效应之间的关系。
Environ Health Perspect. 1994 Oct;102 Suppl 5(Suppl 5):133-7. doi: 10.1289/ehp.94102s5133.
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Deposition of sized glass fibres in the respiratory tract of the rat.大鼠呼吸道中分级玻璃纤维的沉积。
Ann Occup Hyg. 1980;23(4):353-66. doi: 10.1093/annhyg/23.4.353.
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Deposition, retention, and clearance of inhaled particles.吸入颗粒的沉积、滞留和清除
Br J Ind Med. 1980 Nov;37(4):337-62. doi: 10.1136/oem.37.4.337.
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Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals.闪石石棉及其他纤维状矿物质中颗粒尺寸与致癌性的关系。
J Natl Cancer Inst. 1981 Nov;67(5):965-75.
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Chrysotile asbestos inhalation in rats: deposition pattern and reaction of alveolar epithelium and pulmonary macrophages.大鼠吸入温石棉：沉积模式及肺泡上皮和肺巨噬细胞的反应
Am Rev Respir Dis. 1981 Jun;123(6):670-9. doi: 10.1164/arrd.1981.123.6.670.
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Comparative pulmonary responses to inhaled inorganic fibers with asbestos and fiberglass.吸入石棉和玻璃纤维等无机纤维后肺部反应的比较
Environ Res. 1981 Feb;24(1):167-91. doi: 10.1016/0013-9351(81)90143-2.
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Human exposure to asbestos: dust controls and standards. The inhalation of fibrous dusts.人类接触石棉：粉尘控制与标准。纤维性粉尘的吸入。
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Comparative deposition of inhaled aerosols in experimental animals and humans: a review.实验动物和人类中吸入气雾剂的比较沉积：综述
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生物持久性在人造纤维致病性中的作用及生物持久性评估方法：两次圆桌讨论综述

Role of biopersistence in the pathogenicity of man-made fibers and methods for evaluating biopersistence: a summary of two round-table discussions.

作者信息

McClellan R O, Hesterberg T W

机构信息

Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709.

出版信息

Environ Health Perspect. 1994 Oct;102 Suppl 5(Suppl 5):277-83. doi: 10.1289/ehp.94102s5277.

DOI:10.1289/ehp.94102s5277
PMID:7882950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1567306/
Abstract

This paper summarizes two roundtable discussions held at the conclusion of the International Conference on Biopersistence of Respirable Synthetic Fibres and Minerals. The first round table addressed the role of biopersistence in the pathogenicity of fiber-induced disease. The panel included T. W. Hesterberg (Chairman), J.M.G. Davis, K. Donaldson, B. Fubini, N.F. Johnson, G. Oberdoerster, P. Sébastien, and D. Warheit. The second panel addressed the issue of methods for assessing biopersistence. It included R.O. McClellan (Chairman), J. Brain, A. Langer, A. Morgan, C. Morscheidt, H. Muhle, and R. Musselman. The two chairmen acknowledge the excellent contributions of all the members of the panels, whose comments formed the basis of this summary. Nonetheless, the authors assume full responsibility for the written text, recognizing that it was not reviewed by the discussants of the two panels.-Environ Health Perspect 102(Suppl 5):277-283 (1994)

摘要

本文总结了在可吸入合成纤维和矿物质生物持久性国际会议结束时举行的两场圆桌讨论。第一场圆桌会议讨论了生物持久性在纤维诱发疾病致病性中的作用。参与小组讨论的成员包括T.W.赫斯特伯格（主席）、J.M.G.戴维斯、K.唐纳森、B.富比尼、N.F.约翰逊、G.奥伯多斯特、P.塞巴斯蒂安和D.瓦海特。第二场小组讨论的主题是生物持久性评估方法。参与讨论的成员包括R.O.麦克莱伦（主席）、J.布雷恩、A.兰格、A.摩根、C.莫尔谢特、H.米尔和R.穆斯尔曼。两位主席感谢各小组成员的出色贡献，他们的评论构成了本总结的基础。尽管如此，作者对书面文本承担全部责任，并认识到该文本未经两个小组的讨论者审阅。——《环境健康展望》第102卷增刊5：277 - 283页（1994年）