Mazda T, Nakata K, Ota K, Kaminuma Y, Katayama T
Japanese Red Cross Tokyo Metropolitan Blood Center, Tokyo.
Southeast Asian J Trop Med Public Health. 1993;24 Suppl 1:183-6.
In Japan, the major transfusion-associated disease is non-A, non-B hepatitis. We studied the relationship between transfusion history and blood donor antibodies to hepatitis C virus (HCV). The positive rate of antibodies to the HCV nonstructural protein (c100-3) depended on age and the time elapsed since transfusion. The anti-c100-3 ratio for subjects with transfusions made prior to 20 years ago was high. One quarter century ago, a change occurred in national blood policy from paid to non-paid voluntary donations. We also have studied the anti-HCV positive rate among donors with prior transfusion using a second generation HCV test kit which includes anti-HCV core antibody detection. The anti-HCV positive rate for the second generation test was higher than that for the anti-c100-3 test. Introduction of the second generation test is therefore more useful in screening than the anti-c100-3 test for blood programs.
在日本，主要的输血相关疾病是非甲非乙型肝炎。我们研究了输血史与献血者丙型肝炎病毒（HCV）抗体之间的关系。HCV非结构蛋白（c100 - 3）抗体的阳性率取决于年龄和输血后的时间。20年前接受输血的受试者的抗c100 - 3比例较高。四分之一个世纪前，国家血液政策从有偿献血转变为无偿自愿献血。我们还使用包括抗HCV核心抗体检测的第二代HCV检测试剂盒，研究了既往有输血史的献血者中的抗HCV阳性率。第二代检测的抗HCV阳性率高于抗c100 - 3检测。因此，对于血液筛查项目而言，第二代检测比抗c100 - 3检测更有用。
