Hjelle B, Anderson B, Torrez-Martinez N, Song W, Gannon W L, Yates T L
Department of Pathology, University of New Mexico School of Medicine, Albuquerque.
Virology. 1995 Mar 10;207(2):452-9. doi: 10.1006/viro.1995.1104.
We recently described a novel hantavirus (HMV-1) of the western harvest mouse Reithrodontomys megalotis. Screening of 181 additional specimens of Reithrodontomys from the United States and Mexico, including samples of R. mexicanus, R. sumichrasti, and R. gracilis of Costa Rica, for antibodies to hantavirus nucleocapsid protein revealed a widespread enzootic of hantavirus infection. Genetic analyses of 7 S genomes of Reithrodontomys-associated hantaviruses demonstrated that the enzootic of HMV-1 extends from central Mexico into the southwestern United States. A presumed deer mouse hantavirus was found in an R. megalotis animal in Mexico. A highly divergent HMV-1-like virus, tentatively called HMV-2, was identified in a Costa Rican R. mexicanus. These data suggest a longstanding radiation of hantaviruses among New World harvest mice. We identify possible opportunities for genetic exchange among hantaviruses of related rodent hosts.
我们最近描述了一种来自西部收获鼠（Reithrodontomys megalotis）的新型汉坦病毒（HMV-1）。对来自美国和墨西哥的另外181份西部收获鼠标本进行筛查，包括来自墨西哥的墨西哥收获鼠（R. mexicanus）、苏米氏收获鼠（R. sumichrasti）和哥斯达黎加的细收获鼠（R. gracilis）样本，检测其针对汉坦病毒核衣壳蛋白的抗体，结果显示汉坦病毒感染呈广泛的地方性流行。对7个与西部收获鼠相关的汉坦病毒S基因组进行遗传分析表明，HMV-1的地方性流行范围从墨西哥中部延伸至美国西南部。在墨西哥的一只西部收获鼠体内发现了一种推测为鹿鼠汉坦病毒。在哥斯达黎加的一只墨西哥收获鼠中鉴定出一种高度分化的类似HMV-1的病毒，暂称为HMV-2。这些数据表明汉坦病毒在新大陆收获鼠中存在长期的辐射现象。我们确定了相关啮齿动物宿主的汉坦病毒之间可能的基因交换机会。
