沙美特罗与沙丁胺醇对慢性气道阻塞患者疗效的比较。
Comparison of salmefamol and salbutamol in patients with chronic airways obstruction.
作者信息
Campbell I A, Dash C H, McHardy G J, Shotter M V
出版信息
Br J Clin Pharmacol. 1976 Feb;3(1):151-5. doi: 10.1111/j.1365-2125.1976.tb00582.x.
Abstract
1 Inhaled salmefamol, in doses of 100 mug and 200 mug has been compared with inhaled salbutamol, in a dose of 200 mug, and with placebo in patients with airways obstruction. 2 Both salmefamol and salbutamol are potent bronchodilators with a signficantly superior action over placebo at all times up to 8 h after treatment. 3 The mean peak percentage increases in FEV produced by the three active preparations were similar. The decline from peak values was significantly slower with salmefamol than with salbutamol. Neither drug produced tachycardia.
摘要
- 已将剂量为100微克和200微克的吸入用沙美特罗与剂量为200微克的吸入用沙丁胺醇以及安慰剂在气道阻塞患者中进行了比较。2. 沙美特罗和沙丁胺醇均为强效支气管扩张剂，在治疗后长达8小时的所有时间内，其作用均明显优于安慰剂。3. 三种活性制剂引起的第一秒用力呼气容积（FEV）平均峰值百分比增加相似。沙美特罗导致的从峰值下降明显慢于沙丁胺醇。两种药物均未引起心动过速。
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本文引用的文献
1
New class of selective stimulants of beta-adrenergic receptors.新型β-肾上腺素能受体选择性兴奋剂。
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The bronchodilator effect of a new adrenergic aerosol--Salmefamol.一种新型肾上腺素能气雾剂——沙美特罗的支气管扩张作用。
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An economical method of comparing inhaled bronchodilators in reversible diffuse airways obstruction. With special reference to a beta-2 stimulant--salmefamol.一种用于比较可逆性弥漫性气道阻塞中吸入性支气管扩张剂的经济方法。特别提及一种β-2兴奋剂——沙美特罗。
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A double-blind trial of salmefanol, a new bronchodilator.一项关于新型支气管扩张剂沙美法诺的双盲试验。
Postgrad Med J. 1975 Sep;51(599):627-30. doi: 10.1136/pgmj.51.599.627.
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