Loesch D Z, Hopper J L, Rogucka E, Huggins R M
School of Psychology, La Trobe University, Bundoora, Australia.
Am J Hum Genet. 1995 Mar;56(3):753-9.
We have analyzed longitudinal twin data by using a multivariate normal model to identify and quantify genetic effects over time on two main aspects of growth, height and skeletal maturity. The largest genetic contribution to the variance in both height and skeletal maturity coincided with the respective ages of peak growth velocity. The highest genetic covariance between these two traits coincided with the age of greatest acceleration of growth in height. These findings imply the existence of regulatory or structural genes that influence growth in both height and skeletal maturity. We also found sex differences in the rapport between velocities for height and skeletal maturity. These are consistent with a predominant role of estrogen in accelerating skeletal maturation in females, and the existence of additional mechanisms in males which may promote growth in height independently of the effects of gonadal sex steroids.
我们通过使用多变量正态模型分析了纵向双胞胎数据，以识别和量化随时间推移遗传因素对生长的两个主要方面——身高和骨骼成熟度的影响。对身高和骨骼成熟度方差的最大遗传贡献与各自的生长速度峰值年龄相吻合。这两个性状之间的最高遗传协方差与身高增长加速最快的年龄相吻合。这些发现意味着存在影响身高和骨骼成熟度生长的调控或结构基因。我们还发现了身高和骨骼成熟度速度之间关系中的性别差异。这些与雌激素在加速女性骨骼成熟中的主要作用一致，以及男性中存在可能独立于性腺性类固醇作用促进身高增长的其他机制。
