艾滋病中的人类疱疹病毒6型。

Human herpesvirus 6 in AIDS.

作者信息

Lusso P, Gallo R C

机构信息

Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

出版信息

Immunol Today. 1995 Feb;16(2):67-71. doi: 10.1016/0167-5699(95)80090-5.

DOI:10.1016/0167-5699(95)80090-5

PMID:7888069

Abstract

Multiple lines of clinical and experimental evidence suggest that human herpesvirus 6 (HHV-6) may act as an accelerating factor in the natural history of human immunodeficiency virus (HIV) infection. Although, in common with HIV, HHV-6 has a primary tropism for CD4+ T cells, its potential effects on the immune system are broader. For instance, HHV-6 can also infect and kill CD8+ T cells, natural killer cells and mononuclear phagocytes. Here, Paolo Lusso and Robert Gallo suggest that understanding the immunopathogenic role of HHV-6 in the course of HIV infection may shed new light on the complex mechanisms of disease progression in AIDS.

摘要

多条临床和实验证据表明，人类疱疹病毒6型（HHV-6）可能在人类免疫缺陷病毒（HIV）感染的自然病程中起到加速作用。虽然HHV-6与HIV一样，主要嗜性为CD4+ T细胞，但其对免疫系统的潜在影响更为广泛。例如，HHV-6还可感染并杀死CD8+ T细胞、自然杀伤细胞和单核吞噬细胞。在此，保罗·卢索和罗伯特·加洛指出，了解HHV-6在HIV感染过程中的免疫致病作用，可能会为艾滋病疾病进展的复杂机制带来新的认识。