Blázquez M V, Madueño J A, Jurado R, Fernández-Arcás N, Muñoz E
Departamento de Fisiología e Immunología, Facultad de Medicina, Universidad de Córdoba, Spain.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Aug 1;9(4):389-94.
The aim of this study is to investigate the relationship between human herpesvirus type 6 (HHV-6) and cytomegalovirus (CMV) infection and progression of AIDS disease. A group of 52 HIV-1-seropositive patients was examined for HHV-6 DNA expression in peripheral blood mononuclear cells and for CMV DNA in serum. We found that 21.1% (n = 52) and 12% (n = 25) of them tested positive for HHV-6 and CMV DNA, respectively. In contrast, only 3.3% (n = 29) and 0% (n = 29) of control healthy HIV-1-seronegative donors tested positive for HHV-6 and CMV, respectively. In light of these results, the possible role of HHV-6 as a cofactor in AIDS development has also been assessed by closely following, over 6 years, the course of an HIV-1-seropositive person who had a dramatic loss in the total number of CD4+ cells along with a spontaneous production of HIV-1 p24 antigen in vitro and who also showed progression to AIDS when coinfected with HHV-6. These observations have spurred our prospective analysis of the possible clinical significance of coinfection with HHV-6 and HIV.
本研究的目的是调查人类疱疹病毒6型（HHV-6）和巨细胞病毒（CMV）感染与艾滋病病情进展之间的关系。对一组52例HIV-1血清阳性患者检测外周血单个核细胞中的HHV-6 DNA表达及血清中的CMV DNA。我们发现，其中分别有21.1%（n = 52）和12%（n = 25）的患者HHV-6和CMV DNA检测呈阳性。相比之下，在对照健康的HIV-1血清阴性供者中，分别只有3.3%（n = 29）和0%（n = 29）的HHV-6和CMV检测呈阳性。鉴于这些结果，通过对一名HIV-1血清阳性者进行长达6年的密切随访，评估了HHV-6作为艾滋病发展辅助因子的可能作用，该患者CD4+细胞总数急剧减少，体外自发产生HIV-1 p24抗原，并且在合并感染HHV-6时也出现了艾滋病进展。这些观察结果促使我们对HHV-6与HIV合并感染的可能临床意义进行前瞻性分析。
