蓖麻油诱导的大鼠腹泻与肠黏膜损伤的解离：NG-硝基-L-精氨酸甲酯的作用
Dissociation of castor oil-induced diarrhoea and intestinal mucosal injury in rat: effect of NG-nitro-L-arginine methyl ester.
作者信息
Capasso F, Mascolo N, Izzo A A, Gaginella T S
机构信息
Department of Experimental Pharmacology, University of Naples Federico II, Italy.
出版信息
Br J Pharmacol. 1994 Dec;113(4):1127-30. doi: 10.1111/j.1476-5381.1994.tb17113.x.
Abstract
- Castor oil (2 ml orally) produced diarrhoea in rats 1-7 h after challenge, which was associated with gross damage to the duodenal and jejunal mucosa. 2. The injury was accompanied by release of acid phosphatase into the gut lumen, indicating cellular injury. 3. Intraperitoneal injection of the nitric oxide (NO) synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME, 2.5-50 mg kg-1 twice), prevented the diarrhoea. The dose of L-NAME (50 mg kg-1) completely blocked the diarrhoea but increased the release of acid phosphatase and worsened the gross damage. 4. The NO donating compound, isosorbide-5-mononitrate (IMN, 150 mg kg-1 twice) reversed the effects of L-NAME (50 mg kg-1) on castor oil-induced diarrhoea, gross damage and acid phosphatase release. 5. The apparent dissociation of the diarrhoeal and intestinal mucosal damaging effects of castor oil suggest that NO has a protective effect on the rat duodenal and jejunal mucosa, but that NO mediates, in part, the diarrhoea effect of this laxative.
摘要
- 蓖麻油（口服2毫升）在激发后1 - 7小时使大鼠出现腹泻，这与十二指肠和空肠黏膜的严重损伤有关。2. 这种损伤伴随着酸性磷酸酶释放到肠腔中，表明存在细胞损伤。3. 腹腔注射一氧化氮（NO）合酶抑制剂NG - 硝基 - L - 精氨酸甲酯（L - NAME，2.5 - 50毫克/千克，每日两次）可预防腹泻。L - NAME剂量为50毫克/千克时可完全阻断腹泻，但会增加酸性磷酸酶的释放并加重严重损伤。4. 供NO的化合物5 - 单硝酸异山梨酯（IMN，150毫克/千克，每日两次）可逆转L - NAME（50毫克/千克）对蓖麻油诱导的腹泻、严重损伤和酸性磷酸酶释放的影响。5. 蓖麻油腹泻和肠黏膜损伤作用的明显分离表明，NO对大鼠十二指肠和空肠黏膜有保护作用，但NO在一定程度上介导了这种泻药的腹泻作用。
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