Kawano H, Okada R, Kawano Y, Sueyoshi N, Shirai T
Research Laboratory for Cardiovascular Pathology, Juntendo University School of Medicine, Tokyo, Japan.
Jpn Heart J. 1994 Nov;35(6):745-50. doi: 10.1536/ihj.35.745.
Programmed cell death or apoptosis plays a major role in the modification of morphologic and functional maturity in various normal organ systems. However, it is also related to certain diseases. We conducted a pathological study of the apoptosis of cardiomyocytes in six cases with myocarditis (three of acute myocarditis and three of chronic or persistent myocarditis) using histochemical methods. In normal hearts obtained from autopsy cases, apoptosis was seen in endocardial cells. There was no apoptosis in myocardial cells, except for a few in myocytes with two nuclei. In myocarditis, although the myocytes of all cases with acute myocarditis did not show apoptosis, one of the three cases with chronic or persistent myocarditis showed many apoptotic myocytes. Apoptosis may be one of the mechanisms causing myocyte damage in myocarditis.
程序性细胞死亡或凋亡在各种正常器官系统的形态和功能成熟的改变中起主要作用。然而，它也与某些疾病相关。我们使用组织化学方法对6例心肌炎患者（3例急性心肌炎和3例慢性或持续性心肌炎）的心肌细胞凋亡进行了病理学研究。在尸检病例获得的正常心脏中，心内膜细胞可见凋亡。心肌细胞中未发现凋亡，除了少数双核心肌细胞。在心肌炎中，虽然所有急性心肌炎病例的心肌细胞均未显示凋亡，但3例慢性或持续性心肌炎病例中有1例显示许多凋亡心肌细胞。凋亡可能是心肌炎中导致心肌细胞损伤的机制之一。
